The lysosomal transporter MFSD1 is essential for liver homeostasis and critically depends on its accessory subunit GLMP
Identifieur interne : 003F91 ( Main/Exploration ); précédent : 003F90; suivant : 003F92The lysosomal transporter MFSD1 is essential for liver homeostasis and critically depends on its accessory subunit GLMP
Auteurs : David Massa L Pez [Allemagne] ; Melanie Thelen [Allemagne] ; Felix Stahl [Allemagne] ; Christian Thiel [Allemagne] ; Arne Linhorst [Allemagne] ; Marc Sylvester [Allemagne] ; Irm Hermanns-Borgmeyer [Allemagne] ; Renate Lüllmann-Rauch [Allemagne] ; Winnie Eskild [Norvège] ; Paul Saftig [Allemagne] ; Markus Damme [Allemagne]Source :
- eLife [ 2050-084X ] ; ????.
Abstract
Lysosomes are major sites for intracellular, acidic hydrolase-mediated proteolysis and cellular degradation. The export of low-molecular-weight catabolic end-products is facilitated by polytopic transmembrane proteins mediating secondary active or passive transport. A number of these lysosomal transporters, however, remain enigmatic. We present a detailed analysis of MFSD1, a hitherto uncharacterized lysosomal family member of the major facilitator superfamily. MFSD1 is not N-glycosylated. It contains a dileucine-based sorting motif needed for its transport to lysosomes.
Url:
DOI: 10.7554/eLife.50025
PubMed: 31661432
PubMed Central: 6819133
Affiliations:
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strict</wicri:regionArea></affiliation></author><author><name sortKey="Thiel, Christian" sort="Thiel, Christian" uniqKey="Thiel C" first="Christian" last="Thiel">Christian Thiel</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution content-type="dept">Center for Child and Adolescent Medicine, Department of Pediatrics I</institution><institution>University of Heidelberg</institution><addr-line>Heidelberg</addr-line><country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Linhorst, Arne" sort="Linhorst, Arne" uniqKey="Linhorst A" first="Arne" last="Linhorst">Arne Linhorst</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution content-type="dept">Institute of Biochemistry</institution><institution>Christian-Albrechts-University Kiel</institution><addr-line>Kiel</addr-line><country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sylvester, Marc" sort="Sylvester, Marc" uniqKey="Sylvester M" first="Marc" last="Sylvester">Marc Sylvester</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution content-type="dept">Institute for Biochemistry and Molecular Biology</institution><institution>Rheinische-Friedrich-Wilhelms-University</institution><addr-line>Bonn</addr-line><country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hermanns Borgmeyer, Irm" sort="Hermanns Borgmeyer, Irm" uniqKey="Hermanns Borgmeyer I" first="Irm" last="Hermanns-Borgmeyer">Irm Hermanns-Borgmeyer</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution content-type="dept">Center for Molecular Neurobiology</institution><institution>University Medical Center Hamburg-Eppendorf</institution><addr-line>Hamburg</addr-line><country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lullmann Rauch, Renate" sort="Lullmann Rauch, Renate" uniqKey="Lullmann Rauch R" first="Renate" last="Lüllmann-Rauch">Renate Lüllmann-Rauch</name><affiliation wicri:level="1"><nlm:aff id="aff6"><institution content-type="dept">Institute for Anatomy</institution><institution>Christian-Albrechts-University Kiel</institution><addr-line>Kiel</addr-line><country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Eskild, Winnie" sort="Eskild, Winnie" uniqKey="Eskild W" first="Winnie" last="Eskild">Winnie Eskild</name><affiliation wicri:level="1"><nlm:aff id="aff7"><institution content-type="dept">Department of Bioscience</institution><institution>University of Oslo</institution><addr-line>Oslo</addr-line><country>Norway</country></nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Saftig, Paul" sort="Saftig, Paul" uniqKey="Saftig P" first="Paul" last="Saftig">Paul Saftig</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution content-type="dept">Institute of Biochemistry</institution><institution>Christian-Albrechts-University Kiel</institution><addr-line>Kiel</addr-line><country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Damme, Markus" sort="Damme, Markus" uniqKey="Damme M" first="Markus" last="Damme">Markus Damme</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution content-type="dept">Institute of Biochemistry</institution><institution>Christian-Albrechts-University Kiel</institution><addr-line>Kiel</addr-line><country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">eLife</title><idno type="eISSN">2050-084X</idno><imprint><date when="????">????</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Lysosomes are major sites for intracellular, acidic hydrolase-mediated proteolysis and cellular degradation. The export of low-molecular-weight catabolic end-products is facilitated by polytopic transmembrane proteins mediating secondary active or passive transport. A number of these lysosomal transporters, however, remain enigmatic. We present a detailed analysis of MFSD1, a hitherto uncharacterized lysosomal family member of the major facilitator superfamily. MFSD1 is not N-glycosylated. It contains a dileucine-based sorting motif needed for its transport to lysosomes. <italic>Mfsd1</italic> knockout mice develop splenomegaly and severe liver disease. Proteomics of isolated lysosomes from <italic>Mfsd1</italic> knockout mice revealed GLMP as a critical accessory subunit for MFSD1. MFSD1 and GLMP physically interact. GLMP is essential for the maintenance of normal levels of MFSD1 in lysosomes and vice versa. <italic>Glmp</italic> knockout mice mimic the phenotype of <italic>Mfsd1</italic> knockout mice. Our data reveal a tightly linked MFSD1/GLMP lysosomal membrane protein transporter complex.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Abu Remaileh, M" uniqKey="Abu Remaileh M">M Abu-Remaileh</name></author><author><name sortKey="Wyant, Ga" uniqKey="Wyant G">GA Wyant</name></author><author><name sortKey="Kim, C" uniqKey="Kim C">C Kim</name></author><author><name sortKey="Laqtom, Nn" uniqKey="Laqtom N">NN Laqtom</name></author><author><name sortKey="Abbasi, M" uniqKey="Abbasi M">M Abbasi</name></author><author><name sortKey="Chan, Sh" uniqKey="Chan S">SH Chan</name></author><author><name sortKey="Freinkman, E" uniqKey="Freinkman E">E Freinkman</name></author><author><name sortKey="Sabatini, Dm" uniqKey="Sabatini D">DM Sabatini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bagshaw, Rd" uniqKey="Bagshaw R">RD Bagshaw</name></author><author><name sortKey="Mahuran, Dj" uniqKey="Mahuran D">DJ Mahuran</name></author><author><name sortKey="Callahan, Jw" uniqKey="Callahan J">JW Callahan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chapel, A" uniqKey="Chapel A">A Chapel</name></author><author><name sortKey="Kieffer Jaquinod, S" uniqKey="Kieffer Jaquinod S">S Kieffer-Jaquinod</name></author><author><name sortKey="Sagne, C" uniqKey="Sagne C">C Sagné</name></author><author><name sortKey="Verdon, Q" uniqKey="Verdon Q">Q Verdon</name></author><author><name sortKey="Ivaldi, C" uniqKey="Ivaldi C">C Ivaldi</name></author><author><name sortKey="Mellal, M" uniqKey="Mellal M">M Mellal</name></author><author><name sortKey="Thirion, J" uniqKey="Thirion J">J Thirion</name></author><author><name sortKey="Jadot, M" uniqKey="Jadot M">M Jadot</name></author><author><name sortKey="Bruley, C" uniqKey="Bruley C">C Bruley</name></author><author><name sortKey="Garin, J" uniqKey="Garin J">J Garin</name></author><author><name sortKey="Gasnier, B" uniqKey="Gasnier B">B Gasnier</name></author><author><name sortKey="Journet, A" uniqKey="Journet A">A Journet</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Claussen, M" uniqKey="Claussen M">M Claussen</name></author><author><name sortKey="Kubler, B" uniqKey="Kubler B">B Kübler</name></author><author><name sortKey="Wendland, M" uniqKey="Wendland M">M Wendland</name></author><author><name sortKey="Neifer, K" uniqKey="Neifer K">K Neifer</name></author><author><name sortKey="Schmidt, B" uniqKey="Schmidt B">B Schmidt</name></author><author><name sortKey="Zapf, J" uniqKey="Zapf J">J Zapf</name></author><author><name sortKey="Braulke, T" uniqKey="Braulke T">T Braulke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Damme, M" uniqKey="Damme M">M Damme</name></author><author><name sortKey="Morelle, W" uniqKey="Morelle W">W Morelle</name></author><author><name sortKey="Schmidt, B" uniqKey="Schmidt B">B Schmidt</name></author><author><name sortKey="Andersson, C" uniqKey="Andersson C">C Andersson</name></author><author><name sortKey="Fogh, J" uniqKey="Fogh J">J Fogh</name></author><author><name sortKey="Michalski, Jc" uniqKey="Michalski J">JC Michalski</name></author><author><name sortKey="Lubke, T" uniqKey="Lubke T">T Lübke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Deleve, Ld" uniqKey="Deleve L">LD DeLeve</name></author><author><name sortKey="Shulman, Hm" uniqKey="Shulman H">HM Shulman</name></author><author><name sortKey="Mcdonald, Gb" uniqKey="Mcdonald G">GB McDonald</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Della Valle, Mc" uniqKey="Della Valle M">MC Della Valle</name></author><author><name sortKey="Sleat, De" uniqKey="Sleat D">DE Sleat</name></author><author><name sortKey="Zheng, H" uniqKey="Zheng H">H Zheng</name></author><author><name sortKey="Moore, Df" uniqKey="Moore D">DF Moore</name></author><author><name sortKey="Jadot, M" uniqKey="Jadot M">M Jadot</name></author><author><name sortKey="Lobel, P" uniqKey="Lobel P">P Lobel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Do, H" uniqKey="Do H">H Do</name></author><author><name sortKey="Healey, Jf" uniqKey="Healey J">JF Healey</name></author><author><name sortKey="Waller, Ek" uniqKey="Waller E">EK Waller</name></author><author><name sortKey="Lollar, P" uniqKey="Lollar P">P Lollar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fan, Cq" uniqKey="Fan C">CQ Fan</name></author><author><name sortKey="Crawford, Jm" uniqKey="Crawford J">JM Crawford</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fettelschoss, V" uniqKey="Fettelschoss V">V Fettelschoss</name></author><author><name sortKey="Burda, P" uniqKey="Burda P">P Burda</name></author><author><name sortKey="Sagne, C" uniqKey="Sagne C">C Sagné</name></author><author><name sortKey="Coelho, D" uniqKey="Coelho D">D Coelho</name></author><author><name sortKey="De Laet, C" uniqKey="De Laet C">C De Laet</name></author><author><name sortKey="Lutz, S" uniqKey="Lutz S">S Lutz</name></author><author><name sortKey="Suormala, T" uniqKey="Suormala T">T Suormala</name></author><author><name sortKey="Fowler, B" uniqKey="Fowler B">B Fowler</name></author><author><name sortKey="Pietrancosta, N" uniqKey="Pietrancosta N">N Pietrancosta</name></author><author><name sortKey="Gasnier, B" uniqKey="Gasnier B">B Gasnier</name></author><author><name sortKey="Bornhauser, B" uniqKey="Bornhauser B">B Bornhauser</name></author><author><name sortKey="Froese, Ds" uniqKey="Froese D">DS Froese</name></author><author><name sortKey="Baumgartner, Mr" uniqKey="Baumgartner M">MR Baumgartner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gahl, Wa" uniqKey="Gahl W">WA Gahl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Geering, K" uniqKey="Geering K">K Geering</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Halestrap, Ap" uniqKey="Halestrap A">AP Halestrap</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hirata, M" uniqKey="Hirata M">M Hirata</name></author><author><name sortKey="Tajima, H" uniqKey="Tajima H">H Tajima</name></author><author><name sortKey="Miyashita, T" uniqKey="Miyashita T">T Miyashita</name></author><author><name sortKey="Miyata, T" uniqKey="Miyata T">T Miyata</name></author><author><name sortKey="Nakanuma, S" uniqKey="Nakanuma S">S Nakanuma</name></author><author><name sortKey="Makino, I" uniqKey="Makino I">I Makino</name></author><author><name sortKey="Hayashi, H" uniqKey="Hayashi H">H Hayashi</name></author><author><name sortKey="Oyama, K" uniqKey="Oyama K">K Oyama</name></author><author><name sortKey="Takamura, H" uniqKey="Takamura H">H Takamura</name></author><author><name sortKey="Ninomiya, I" uniqKey="Ninomiya I">I Ninomiya</name></author><author><name sortKey="Fushida, S" uniqKey="Fushida S">S Fushida</name></author><author><name sortKey="Nakata, H" uniqKey="Nakata H">H Nakata</name></author><author><name sortKey="Iseki, S" uniqKey="Iseki S">S Iseki</name></author><author><name sortKey="Harada, S" uniqKey="Harada S">S Harada</name></author><author><name sortKey="Wakayama, T" uniqKey="Wakayama T">T Wakayama</name></author><author><name sortKey="Ohta, T" uniqKey="Ohta T">T Ohta</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kelley, La" uniqKey="Kelley L">LA Kelley</name></author><author><name sortKey="Mezulis, S" uniqKey="Mezulis S">S Mezulis</name></author><author><name sortKey="Yates, Cm" uniqKey="Yates C">CM Yates</name></author><author><name sortKey="Wass, Mn" uniqKey="Wass M">MN Wass</name></author><author><name sortKey="Sternberg, Mj" uniqKey="Sternberg M">MJ Sternberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Koch, T" uniqKey="Koch T">T Koch</name></author><author><name sortKey="Dahl, C" uniqKey="Dahl C">C Dahl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kong, Xy" uniqKey="Kong X">XY Kong</name></author><author><name sortKey="Nesset, Ck" uniqKey="Nesset C">CK Nesset</name></author><author><name sortKey="Damme, M" uniqKey="Damme M">M Damme</name></author><author><name sortKey="L Berg, Em" uniqKey="L Berg E">EM Løberg</name></author><author><name sortKey="Lubke, T" uniqKey="Lubke T">T Lübke</name></author><author><name sortKey="M Hlen, J" uniqKey="M Hlen J">J Mæhlen</name></author><author><name sortKey="Andersson, Kb" uniqKey="Andersson K">KB Andersson</name></author><author><name sortKey="Lorenzo, Pi" uniqKey="Lorenzo P">PI Lorenzo</name></author><author><name sortKey="Roos, N" uniqKey="Roos N">N Roos</name></author><author><name sortKey="Thoresen, Gh" uniqKey="Thoresen G">GH Thoresen</name></author><author><name sortKey="Rustan, Ac" uniqKey="Rustan A">AC Rustan</name></author><author><name sortKey="Kase, Et" uniqKey="Kase E">ET Kase</name></author><author><name sortKey="Eskild, W" uniqKey="Eskild W">W Eskild</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lange, Pf" uniqKey="Lange P">PF Lange</name></author><author><name sortKey="Wartosch, L" uniqKey="Wartosch L">L Wartosch</name></author><author><name sortKey="Jentsch, Tj" uniqKey="Jentsch T">TJ Jentsch</name></author><author><name sortKey="Fuhrmann, Jc" uniqKey="Fuhrmann J">JC Fuhrmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leisle, L" uniqKey="Leisle L">L Leisle</name></author><author><name sortKey="Ludwig, Cf" uniqKey="Ludwig C">CF Ludwig</name></author><author><name sortKey="Wagner, Fa" uniqKey="Wagner F">FA Wagner</name></author><author><name sortKey="Jentsch, Tj" uniqKey="Jentsch T">TJ Jentsch</name></author><author><name sortKey="Stauber, T" uniqKey="Stauber T">T Stauber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Markmann, S" uniqKey="Markmann S">S Markmann</name></author><author><name sortKey="Krambeck, S" uniqKey="Krambeck S">S Krambeck</name></author><author><name sortKey="Hughes, Cj" uniqKey="Hughes C">CJ Hughes</name></author><author><name sortKey="Mirzaian, M" uniqKey="Mirzaian M">M Mirzaian</name></author><author><name sortKey="Aerts, Jm" uniqKey="Aerts J">JM Aerts</name></author><author><name sortKey="Saftig, P" uniqKey="Saftig P">P Saftig</name></author><author><name sortKey="Schweizer, M" uniqKey="Schweizer M">M Schweizer</name></author><author><name sortKey="Vissers, Jp" uniqKey="Vissers J">JP Vissers</name></author><author><name sortKey="Braulke, T" uniqKey="Braulke T">T Braulke</name></author><author><name sortKey="Damme, M" uniqKey="Damme M">M Damme</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Palmieri, M" uniqKey="Palmieri M">M Palmieri</name></author><author><name sortKey="Impey, S" uniqKey="Impey S">S Impey</name></author><author><name sortKey="Kang, H" uniqKey="Kang H">H Kang</name></author><author><name sortKey="Di Ronza, A" uniqKey="Di Ronza A">A di Ronza</name></author><author><name sortKey="Pelz, C" uniqKey="Pelz C">C Pelz</name></author><author><name sortKey="Sardiello, M" uniqKey="Sardiello M">M Sardiello</name></author><author><name sortKey="Ballabio, A" uniqKey="Ballabio A">A Ballabio</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pao, Ss" uniqKey="Pao S">SS Pao</name></author><author><name sortKey="Paulsen, It" uniqKey="Paulsen I">IT Paulsen</name></author><author><name sortKey="Saier, Mh" uniqKey="Saier M">MH Saier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Perland, E" uniqKey="Perland E">E Perland</name></author><author><name sortKey="Hellsten, Sv" uniqKey="Hellsten S">SV Hellsten</name></author><author><name sortKey="Lekholm, E" uniqKey="Lekholm E">E Lekholm</name></author><author><name sortKey="Eriksson, Mm" uniqKey="Eriksson M">MM Eriksson</name></author><author><name sortKey="Arapi, V" uniqKey="Arapi V">V Arapi</name></author><author><name sortKey="Fredriksson, R" uniqKey="Fredriksson R">R Fredriksson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pisoni, Rl" uniqKey="Pisoni R">RL Pisoni</name></author><author><name sortKey="Thoene, Jg" uniqKey="Thoene J">JG Thoene</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pongs, O" uniqKey="Pongs O">O Pongs</name></author><author><name sortKey="Schwarz, Jr" uniqKey="Schwarz J">JR Schwarz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Quistgaard, Em" uniqKey="Quistgaard E">EM Quistgaard</name></author><author><name sortKey="Low, C" uniqKey="Low C">C Löw</name></author><author><name sortKey="Guettou, F" uniqKey="Guettou F">F Guettou</name></author><author><name sortKey="Nordlund, P" uniqKey="Nordlund P">P Nordlund</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reddy, Vs" uniqKey="Reddy V">VS Reddy</name></author><author><name sortKey="Shlykov, Ma" uniqKey="Shlykov M">MA Shlykov</name></author><author><name sortKey="Castillo, R" uniqKey="Castillo R">R Castillo</name></author><author><name sortKey="Sun, Ei" uniqKey="Sun E">EI Sun</name></author><author><name sortKey="Saier, Mh" uniqKey="Saier M">MH Saier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saftig, P" uniqKey="Saftig P">P Saftig</name></author><author><name sortKey="Klumperman, J" uniqKey="Klumperman J">J Klumperman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sauer, Jd" uniqKey="Sauer J">JD Sauer</name></author><author><name sortKey="Bachman, Ma" uniqKey="Bachman M">MA Bachman</name></author><author><name sortKey="Swanson, Ms" uniqKey="Swanson M">MS Swanson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schieweck, O" uniqKey="Schieweck O">O Schieweck</name></author><author><name sortKey="Damme, M" uniqKey="Damme M">M Damme</name></author><author><name sortKey="Schroder, B" uniqKey="Schroder B">B Schröder</name></author><author><name sortKey="Hasilik, A" uniqKey="Hasilik A">A Hasilik</name></author><author><name sortKey="Schmidt, B" uniqKey="Schmidt B">B Schmidt</name></author><author><name sortKey="Lubke, T" uniqKey="Lubke T">T Lübke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schroder, B" uniqKey="Schroder B">B Schröder</name></author><author><name sortKey="Wrocklage, C" uniqKey="Wrocklage C">C Wrocklage</name></author><author><name sortKey="Pan, C" uniqKey="Pan C">C Pan</name></author><author><name sortKey="J Ger, R" uniqKey="J Ger R">R Jäger</name></author><author><name sortKey="Kosters, B" uniqKey="Kosters B">B Kösters</name></author><author><name sortKey="Sch Fer, H" uniqKey="Sch Fer H">H Schäfer</name></author><author><name sortKey="Els Sser, Hp" uniqKey="Els Sser H">HP Elsässer</name></author><author><name sortKey="Mann, M" uniqKey="Mann M">M Mann</name></author><author><name sortKey="Hasilik, A" uniqKey="Hasilik A">A Hasilik</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thelen, M" uniqKey="Thelen M">M Thelen</name></author><author><name sortKey="Winter, D" uniqKey="Winter D">D Winter</name></author><author><name sortKey="Braulke, T" uniqKey="Braulke T">T Braulke</name></author><author><name sortKey="Gieselmann, V" uniqKey="Gieselmann V">V Gieselmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thomas, Pd" uniqKey="Thomas P">PD Thomas</name></author><author><name sortKey="Kejariwal, A" uniqKey="Kejariwal A">A Kejariwal</name></author><author><name sortKey="Campbell, Mj" uniqKey="Campbell M">MJ Campbell</name></author><author><name sortKey="Mi, H" uniqKey="Mi H">H Mi</name></author><author><name sortKey="Diemer, K" uniqKey="Diemer K">K Diemer</name></author><author><name sortKey="Guo, N" uniqKey="Guo N">N Guo</name></author><author><name sortKey="Ladunga, I" uniqKey="Ladunga I">I Ladunga</name></author><author><name sortKey="Ulitsky Lazareva, B" uniqKey="Ulitsky Lazareva B">B Ulitsky-Lazareva</name></author><author><name sortKey="Muruganujan, A" uniqKey="Muruganujan A">A Muruganujan</name></author><author><name sortKey="Rabkin, S" uniqKey="Rabkin S">S Rabkin</name></author><author><name sortKey="Vandergriff, Ja" uniqKey="Vandergriff J">JA Vandergriff</name></author><author><name sortKey="Doremieux, O" uniqKey="Doremieux O">O Doremieux</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Valoskova, K" uniqKey="Valoskova K">K Valoskova</name></author><author><name sortKey="Biebl, J" uniqKey="Biebl J">J Biebl</name></author><author><name sortKey="Roblek, M" uniqKey="Roblek M">M Roblek</name></author><author><name sortKey="Emtenani, S" uniqKey="Emtenani S">S Emtenani</name></author><author><name sortKey="Gyoergy, A" uniqKey="Gyoergy A">A Gyoergy</name></author><author><name sortKey="Misova, M" uniqKey="Misova M">M Misova</name></author><author><name sortKey="Ratheesh, A" uniqKey="Ratheesh A">A Ratheesh</name></author><author><name sortKey="Reis Rodrigues, P" uniqKey="Reis Rodrigues P">P Reis-Rodrigues</name></author><author><name sortKey="Shkarina, K" uniqKey="Shkarina K">K Shkarina</name></author><author><name sortKey="Larsen, Isb" uniqKey="Larsen I">ISB Larsen</name></author><author><name sortKey="Vakhrushev, Sy" uniqKey="Vakhrushev S">SY Vakhrushev</name></author><author><name sortKey="Clausen, H" uniqKey="Clausen H">H Clausen</name></author><author><name sortKey="Siekhaus, De" uniqKey="Siekhaus D">DE Siekhaus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wilke, S" uniqKey="Wilke S">S Wilke</name></author><author><name sortKey="Krausze, J" uniqKey="Krausze J">J Krausze</name></author><author><name sortKey="Bussow, K" uniqKey="Bussow K">K Büssow</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yu, Z" uniqKey="Yu Z">Z Yu</name></author><author><name sortKey="Surface, Le" uniqKey="Surface L">LE Surface</name></author><author><name sortKey="Park, Cy" uniqKey="Park C">CY Park</name></author><author><name sortKey="Horlbeck, Ma" uniqKey="Horlbeck M">MA Horlbeck</name></author><author><name sortKey="Wyant, Ga" uniqKey="Wyant G">GA Wyant</name></author><author><name sortKey="Abu Remaileh, M" uniqKey="Abu Remaileh M">M Abu-Remaileh</name></author><author><name sortKey="Peterson, Tr" uniqKey="Peterson T">TR Peterson</name></author><author><name sortKey="Sabatini, Dm" uniqKey="Sabatini D">DM Sabatini</name></author><author><name sortKey="Weissman, Js" uniqKey="Weissman J">JS Weissman</name></author><author><name sortKey="O Shea, Ek" uniqKey="O Shea E">EK O'Shea</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zheng, L" uniqKey="Zheng L">L Zheng</name></author><author><name sortKey="Baumann, U" uniqKey="Baumann U">U Baumann</name></author><author><name sortKey="Reymond, Jl" uniqKey="Reymond J">JL Reymond</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li><li>Norvège</li></country></list><tree><country name="Allemagne"><noRegion><name sortKey="Massa L Pez, David" sort="Massa L Pez, David" uniqKey="Massa L Pez D" first="David" last="Massa L Pez">David Massa L Pez</name></noRegion><name sortKey="Damme, Markus" sort="Damme, Markus" uniqKey="Damme M" first="Markus" last="Damme">Markus Damme</name><name sortKey="Hermanns Borgmeyer, Irm" sort="Hermanns Borgmeyer, Irm" uniqKey="Hermanns Borgmeyer I" first="Irm" last="Hermanns-Borgmeyer">Irm Hermanns-Borgmeyer</name><name sortKey="Linhorst, Arne" sort="Linhorst, Arne" uniqKey="Linhorst A" first="Arne" last="Linhorst">Arne Linhorst</name><name sortKey="Lullmann Rauch, Renate" sort="Lullmann Rauch, Renate" uniqKey="Lullmann Rauch R" first="Renate" last="Lüllmann-Rauch">Renate Lüllmann-Rauch</name><name sortKey="Saftig, Paul" sort="Saftig, Paul" uniqKey="Saftig P" first="Paul" last="Saftig">Paul Saftig</name><name sortKey="Stahl, Felix" sort="Stahl, Felix" uniqKey="Stahl F" first="Felix" last="Stahl">Felix Stahl</name><name sortKey="Sylvester, Marc" sort="Sylvester, Marc" uniqKey="Sylvester M" first="Marc" last="Sylvester">Marc Sylvester</name><name sortKey="Thelen, Melanie" sort="Thelen, Melanie" uniqKey="Thelen M" first="Melanie" last="Thelen">Melanie Thelen</name><name sortKey="Thiel, Christian" sort="Thiel, Christian" uniqKey="Thiel C" first="Christian" last="Thiel">Christian Thiel</name></country><country name="Norvège"><noRegion><name sortKey="Eskild, Winnie" sort="Eskild, Winnie" uniqKey="Eskild W" first="Winnie" last="Eskild">Winnie 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